No, you can group any hard disk drives (No Init) that are available on the SATA channels of the NAS-7410. In order to gain better performance for RAID device, we suggest to group hard disk drives located in the different SATA channels. For example, you have 6 hard disk drives connected to the NAS-7410 and you want to create two RAID level 5 devices. RAID group A should consist of HD1, HD3, HD5 (all drives connected as "master" devices), and RAID group B should consist of HD2, HD4, HD6 (all drives connected as "slave" devices).